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Combo-pilling is the newest fad or in addition to this the newest in the future under scrutiny and so it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is now popular could be the fact that at the time of right now there are no long term prescription weight loss supplements that have been authorized by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug may also raise blood pressure level and heartbeat, and mustn't be used in those with a history of heart attack or stroke in the previous six months. 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