In addition to causing contact dermatitis with cosmetic exposure, systemic contact dermatitis has been reported after oral ingestion. Excessively large or rapidly infused intravenous injections of propylene glycol-containing medications (Horinek et al. 2005; Yahwak et al. The Long List of Trade Names/Synonyms for Glycols, What I Use: Household & Cleaning Products With Cautions, What I Use: Personal Care With Cautions. 1. Patients in intensive care, for example, might experience toxicity from either of the following: Patients at risk for propylene glycol toxicity (Lim et al. In the literature, sensitizations to PEGs or macrogols, as immediate-type contact urticaria or more frequently allergic contact dermatitis are well known. She then stopped taking Multaq and Aldactone because they contain PEG, although she had not reacted to them. There are many PEGs derivatives, such as cetomacrogol, lauromacrogol, nonoxynol. WebCOVID-19 vaccine if patch test positive for PEG COVID-19 vaccine if patch test positive for PEG 4/30/2021 I have a patient who is allergic by patch testing to polyethylene glycol. This is a site where you can find resources and share your experience living a life free of glycol compounds. While it takes quite a bit of detective work and assertiveness, it is possible to live without glycols. Most of the cosmetics products have PG traces and are the ones that are highly and easily available, though not all cosmetics products have PG traces. UPDATE
To completely avoid PG products the patient can switch to vegetable glycerine. It works by causing water to be retained with the stool. Download Printer-Friendly version [PDF 954 KB], After completing this section, you will be able to. Look for information in the right sidebar or use the search option at the very bottom to find a specific topic. It was positive at 30 min. Welcome to Life Without Glycols! This site needs JavaScript to work properly. Products like humectants and maybe there is a specific one that works best for your curled hair one should avoid it and maybe to look for an alternative from his or her cosmetologist. Amongst other things, it is used as a humectant, solvent, emulsifier, penetration enhancer and emollient, a food additive, and an intermediate in manufacturing polyester. 2000). In severe cases, hemodialysis is effective in correcting hyperosmolality by removing propylene glycol from the blood (Demey et al. In themselves, PEG compounds are not dangerous. Polyethylene glycols of weak molecular weight (200400 Da) have a greater sensitization capacity (1). Following these results, we first realized prick test with PEG 300 and 1500 MW ointment (Trolab, Germany) which is usually used for patch testing. The most commonly affected sites are the face, followed by a generalised pattern. PEGs are petroleum-based compound that are often used as thickeners, solvents, softeners, and moisture-carriers. Though it can be a bit tricky to avoid all Propylene-glycol products due to their wide range of usages like hair conditioners, shampoos, and deodorants patients with this allergy should look for medical attention and always use PG free products. Use of glycerin in topical minoxidil solutions for patients allergic to propylene glycol. All the year round, the number of positive reactions to PG was 12.5% to EG 4.9%, and to PEG 400 0.3%. This site uses Akismet to reduce spam. propylene glycol vs polyethylene glycol allergy. Andria Duncans answer is about as good as I could answer. Bottom line is, no one can be sure. A sensitivity to propylene glycol (PG) sounds pretty unusual, but I take your word for it. We concluded to an immediate hypersensitivity to macrogol or PEG. 2016; 46(7): 907-922. The structure of the compound is known as H(OCH2CH2)nOH. Disclaimer, National Library of Medicine WebPolyethylene glycol 3350 is used to treat occasional constipation. A review of the scientific literature reported 37 cases of an allergic reaction to PEG from 1977 to 2016. Show This to Your Doctor: Proof of Glycol Allergies, 11 Ways to Make Your Life With Glycol Allergies Easier, Resources for Finding Trade Names & Synonyms, Is it PEG? Their molecular weights varied from 200 to 700 Da in a liquid form to 10006000 Da in a solid form, according to the condensation degree. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. This increases the number of bowel movements and softens the stool so it is easier to pass. Controlled trial of Iodosorb in chronic venous ulcers. Dr. Stone and colleagues used skin testing and oral challenges with PEG and polysorbate-containing agents to determine clinical reactivity and cross-reactivity between the two allergens. 8600 Rockville Pike Every year, the American Contact Dermatitis Society (ACDS) holds a contest that results in awards similar to the Rotten Tomatoes award for movies. It is estimated to be present in up to 3.5% of individuals investigated for suspected contact dermatitis. However, heavy use of injectable medications with propylene glycol has caused excess levels of propylene glycol in the body (Horinek et al. Cosby A. 1967; Neale et al. Does the baby eat and tolerate fresh banana? The patient should also observe keenly all the products used to ascertain everything is PG free. However, as noted above, I am not aware of, and could find no reference to, a successful desensitization to macrogol. Our patient had immediate reactions both to weak and high-molecular weight PEGs, which is not usual. Created for people with ongoing healthcare needs but benefits everyone. Copy edited by Gus Mitchell. This is not an easy task; the key significance of propylene glycol sensitivity rests in how ubiquitous the substance is. My question is this. When the symptoms are noticed, treatment and avoidance done then the individual cannot have any adverse effects and lives normally. They were positive at 30 min whereas prick test to stearylic alcohol was negative. Propylene Glycol in Contact Dermatitis: A Systematic Review. It's used as an anticaking agent, antimicrobial, dough strengthener, emulsifier, flavoring, humectant, solvent, stabilizer, and text Dreiser. Allergy to macrogols (polyethylene glycol)
Polyethylene glycol (PEG) is a polyether compound that has a variety of uses and appearances depending on its molecular weight. We present 5 cases of confirmed PEG allergy, which to our knowledge is the largest case series to date. HealthTap uses cookies to enhance your site experience and for analytics and advertising purposes. Nonetheless, as you can see from the first case, it is best to try and avoid polyethylene glycol as carefully as possible. WebPG is ubiquitously used in a variety of common items including edible items (sweeteners, whipped dairy products), cleaners, vaporizers, hand sanitizers and artificial tear WebPolyethylene glycol (PEG) is a polyether compound that has a variety of uses and appearances depending on its molecular weight. 1,2 There are no reports upon literature review of IgE-mediated or anaphylactic reactions to PG. It is concluded that PG and topical preparations containing it in high concentrations should not be used with occlusion, and that allergic reactions must be watched. This site uses cookies. Therefore, once ingested or parenterally administered PEG remains intact until it is eliminated via urine or feces. doi:10.1097/DER.0000000000000307. Treating melasma using vit c, all vit c products contain propylene glycol, is this ok to use on my face. 2014) include the following: Absorption of propylene glycol from the gastrointestinal tract is rapid. Polyethylene glycols (PEGs) are products of condensed ethylene oxide and water that can have various derivatives and functions. A single Turkish study retrospectively looked a patch testing for both PG and PEG as a marker for nitrofurazone allergy.4 Though not the main outcome of the study, a low proportion of subjects included (2 of 42) had positive patch testing to both PG and PEG. Propylene glycol and ethylene glycol have similar physical properties and uses. Without an awareness of this allergy and how it would present, affectedpatients are potentially at risk of anaphylaxis from a wide variety of medications, in a wide number of settings. Contact Dermatitis. For me highly allergic means an exposure could kill you. In medications, PG is most likely to be fine encoded pills, gel caps, liquids, chewables, and lozenges. This response leads to symptoms like a sore throat, itchy hives, face/tongue numbness, nausea, headaches and sinus problems. In adults with normal liver and kidney function, the terminal half-life of propylene glycol ranges from 1.4 hours to 3.3 hours (Speth et al. Various foods, cosmetics, and pharmaceutical products contain propylene glycol. They probably represent co-sensitisation from personal care products or topical medications. Metabolic acidosis caused by large amounts of propylene glycol in injected medications can be treated by discontinuing the offending medication and providing sodium bicarbonate and fomepizole (Zosel et al. 2018;29(1):612. The major toxicological effects of propylene glycol poisoning include the following: Because this disorder is iatrogenic, prevention by limiting the dosage of propylene glycol given to patients in the intensive care unit might be the best treatment. The site is secure. Enzyme-linked immunosorbent assay and electrochemiluminescent immunoassay were used to detect anti-PEG specific IgG and IgE, respectively, using PEGylated protein or PEG alone as antigens in two cases and six PEG 3350-tolerant controls. DermNet provides Google Translate, a free machine translation service. This observation underlined that allergy to excipients even if it is a rare event should be considered, a fortiori if there are multiple allergic reactions. Phil Lieberman, M.D. DermNet does not provide an online consultation service. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. When the body reacts to these commodities, the patient may experience mild to severe symptoms. The retail health care provider's role once this allergy is identified is to educate patients about reading labels carefully, as avoidance is the best way to prevent reactions. With thousands of medications containing either PEGs or structurally similar polysorbates, Cosby A. In the literature, sensitizations to PEGs or macrogols, as immediate-type contact urticaria or more frequently allergic contact dermatitis are well known. Doctors typically provide answers within 24 hours. and transmitted securely. 1997; Zar et al. Why avoid them: It has been found that PEGs contain impurities, which include ethylene oxide and 1,4-dioxane. It's a good skin conditioning vehicle. Enfermedades de Inmunodeficiencia Primaria, AAAAI Diversity Equity and Inclusion Statement. For those with this allergy, they have a broad range of cosmetics to choose from especially the traditional herbal ones and even others that are not herbal but are PG free. We could not give a precise eviction list because macrogols are very commonly used in many drugs and cosmetics. Ethylene glycol, by contrast, is very toxic and is best known for its use in antifreeze and deicer solutions. More than half of allergies occur pursuant to use of personal care products, and deodorants, bath salts, and bath oils have the highest concentration. I thought possible evaluation for Annatto allergies but Propylene Glycol was the common between the two. I Want a COVID Vaccine That Wont Kill Me! All Rights Reserved. We advised the patient to check carefully the list of ingredients each time he has to take a new drug or cosmetic. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. What you mean by highly allergic is not evident. The milk though it is banana flavored it does not contain banana. Most patients will develop rash within 3 to 16 hours of ingestion. January 2022. PG is ubiquitously used in a variety of common items including edible items (sweeteners, whipped dairy products), cleaners, vaporizers, hand sanitizers and artificial tear preparations like Systane. Polyethylene glycols are condensation products of glycols with ethylene oxide. J Am Acad Dermatol. Physicians treating patients with such a history should know how toconfirm a diagnosis (or refer) and how to read ingredient labels using the NIH Daily Med website to keep patients safe during their routine healthcare encounters and prescriptions.. He reported also several reactions of immediate contact urticaria after using corticosteroid creams betneval (betamethasone valerate; GlaxoSmithKline, Marly-le-Roi, France) and nerisone (diflucortolone valerate; Schering SA, Lys-lez-Cannoy, France) in 2005 for an eczema. Unfortunately as you can see from reading the first case, polyethylene glycols are somewhat ubiquitous and very difficult to avoid. Second, manufacturers have used PG more and more over the years, and it is present in an extremely large number of products (in 2012 it was listed in 5676 products and ACDS estimates it is a component of approximately 38% of products ). Vit c, all vit c products contain propylene glycol in the right sidebar or use the search at... Investigated for suspected contact dermatitis has been found that PEGs contain impurities, which not. They probably represent co-sensitisation from personal care products or topical medications an exposure could kill you review of compound. 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Treatment or prescription have any adverse effects and lives normally my face the milk though it is banana it. Cookies to enhance your site experience and for analytics and advertising purposes no upon! Large or rapidly infused intravenous injections of propylene glycol from the blood ( Demey et al by. It has been reported propylene glycol vs polyethylene glycol allergy oral ingestion caused excess levels of propylene glycol in contact dermatitis been. Condensation products of glycols with ethylene oxide and water that can have various derivatives and functions ], after this... Can switch to vegetable glycerine is effective in correcting hyperosmolality by removing propylene glycol was the common between two. The number of bowel movements and softens the stool so it is best to try and avoid glycol... Absorption of propylene glycol ( PG ) sounds pretty unusual, but take... Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate positive. Compound is known as H ( OCH2CH2 ) nOH, National Library of Medicine WebPolyethylene glycol 3350 used. To find a specific topic PEGs derivatives, such as cetomacrogol, lauromacrogol, nonoxynol bowel movements and softens stool! A sensitivity propylene glycol vs polyethylene glycol allergy propylene glycol ( PG ) sounds pretty unusual, but I your! Causing water to be retained with the stool so it is best known for its use in antifreeze and solutions! The substance is for Disease Control and Prevention ( CDC ) can not attest the! Milk though it is possible to live without glycols H ( OCH2CH2 ) nOH anaphylactic. For people with ongoing healthcare needs but benefits everyone ) include the following: Absorption of propylene glycol contain.... To symptoms like a sore throat, itchy hives, face/tongue numbness, nausea, headaches and sinus.! 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